Posachedwapa, bakiteriya yotchedwa Desulfovibrio Vulgaris (Desulfovibrio Vulgaris), yotulutsa mphamvu kwambiri ya acetic acid, yasindikizidwa pa intaneti mu magazini yapadziko lonse ya Microbiology yolembedwa ndi Gut Microbes (District 1). Bakiteriya yotulutsa acetic acid wamphamvu, imachepetsera matenda a chiwindi chamafuta osaledzeretsa mu mbewa.

Matenda a chiwindi osaledzeretsa (NAFLD) ndi matenda ofala kwambiri a chiwindi, ndipo pakalipano pali kusowa kwa mankhwala othandiza. Kafukufuku wambiri wasonyeza kuti matumbo a microbiota ndi chinthu chofunikira kwambiri pa matenda a kunenepa kwambiri okhudzana ndi kunenepa kwambiri. Chifukwa chake, kutsata malamulo a matumbo a microbiota kumawonedwa ngati njira yatsopano yopewera komanso kuchiza matenda a metabolic.

Kuthamangitsidwa ndi mtundu wachilengedwe wa macromolecular mankhwala omwe amafalitsidwa kwambiri mumankhwala achi China. Kafukufuku wambiri wasonyeza kuti ma polysaccharides a zomera ali ndi zotsatira zotsimikizika pa kayendetsedwe ka kagayidwe kake, koma makina enieniwo sali omveka bwino. Gulu la Houkai Li lidawonetsa m'maphunziro am'mbuyomu kuti astragalus membranaceus polysaccharides, gawo lalikulu la astragalus membranaceus, limatha kusintha kunenepa kwambiri ndi NAFLD, ndikuwona kuwongolera kwa ASTRagalus membranaceus polysaccharides pamatumbo am'mimba ndi metabolites kudzera mu kusanthula kwa metagenomic metabonomic metabolites. The olamulira Lingaliro la "mankhwala-intestinal microbiota - metabolite - khamu kagayidwe" anali akufuna kusintha NAFLD mapangidwe ndi APS.

Kutengera malingaliro asayansi awa, gulu lofufuzira linafufuza mabakiteriya enieni a m'mimba ndi ma metabolites ogwirizana omwe amayendetsedwa ndi APS kudzera mu njira yophatikizira ma multi-omics, ndipo adapeza kuti KUSINTHA kwa NAFLD ndi APS sikungokhala ndi mawonekedwe a kudalira kwamaluwa, komanso kumatha kulemeretsa matumbo. mabakiteriya (Desulfovibrio Vulgaris). Kufufuza kwina kunatsimikizira kuti bakiteriyayo sanali wopangidwa mwachilengedwe wa H2S, komanso anali ndi luso lopanga acetic acid. Kuphatikizika kwachilendo kwa bakiteriya iyi kunathandizira kwambiri hepatic steatosis, kumva kwa insulin komanso kunenepa kwambiri kwa mbewa zomwe zimadyetsedwa ndi zakudya zamafuta ambiri. Kupyolera mu kusanthula kwa RNA SEQ ya chiwindi ndi kafukufuku wa biology ya maselo, zinatsimikiziridwa kuti kusintha kwa NAFLD kunali kokhudzana ndi kuletsa kwa chiwindi FASN ndi CD36 protein expression. Kafukufukuyu adapereka umboni watsopano wofotokozera momwe APS amagwirira ntchito pakuwongolera NAFLD, komanso adaperekanso zowunikira pakuwunika momwe APS amayendera m'matumbo ndikuwongolera kagayidwe kazakudya mothandizidwa ndiukadaulo wa multiomics.

Kusanthula kwa zigawo za astragalus polysaccharide monosaccharide mu kafukufukuyu kudathandizidwa ndi gulu la Pulofesa Ding Kan waku Shanghai Institute of Materia Medica, Chinese Academy of Sciences, ndipo ma metabolomics ndi kapangidwe ka maphunziro adathandizidwa kwambiri ndi gulu la Pulofesa Jia Wei waku The Sixth People's Hospital yogwirizana. ku Shanghai Jiao Tong University. Ningning Zheng ndi Wei Jia ndi olemba limodzi a pepalali. Hong Ying, yemwe ndi dokotala wa gulu la Pulofesa Li Houkai, ndiye mlembi woyamba wa pepalali, ndipo Shanghai University of Traditional Chinese Medicine ndiye woyamba kusaina pepalalo. Kafukufukuyu adathandizidwa ndi National Natural Science Research Foundation ya China.